Start Outlook without starting Lync and check to see if the issue persists. Click on the “ Disable” button and restart your computer. Click on the “ Startup” tab and select the “ Lync” application from the list. Press “ Windows” + “ X” keys simultaneously and select “ Task Manager” from the list. Therefore, in this step, we will be disabling Lync at startup and open Outlook again. Often, it interferes with important elements of the Outlook application. Lync is a business version of the Skype application. In advanced, c heck all three boxes for Use cached exchange mode, Download shared folders and Download public folder favorites. Click Start and search for Control Panel. Go to CP, and type Mail in the search box on the top right. Click on Mail icon in the search results. In the Mail setup window, click Data Files. Select Your Account, and click Settings. This method is applicable to exchange users only. 
Locate the following programs and uninstall them. If it still won’t work then Hold the Windows Key and Press R. Uncheck all the items in Add-Ins available list and click OK. To disable add-ins, click File -> Options -> Add-ins -> COM Add-ins -> Manage -> Go. Disable all add-ins and then open Outlook to confirm, if it works then enable add-in one by one until you get to the one which stops Outlook. If it works in Safe Mode, then the is likely to be a conflicting or corrupt add-in. If there is only one profile, then it will be selected by default. You will be asked which profile to use when logging in. In the run dialog, type outlook.exe /safe and press Enter. Now open Outlook to see if it works or not, if it still won’t work, then proceed with Method 2. Right-click the Outlook.xml file and choose rename, and add. In the run dialog box type %appdata%\Microsoft\Outlook To do this, Hold the Windows Key and Press R. If it still won’t open after resetting the navigation pane, or if it gives an error, close/exit out of any error pop-ups and rename the Outlook.xml file to. In the run dialog, type, and press Enter. 
In this solution, we will reset the navigation pane settings in Outlook. Add-in’s can also interrupt Outlook from accessing the data file. Secondly, make sure that the file has not been moved from it’s original location. Before going through the steps listed below, make sure that you are not running any back up software’s that is supposed to backup the data file, because if the file is in use, then Outlook will not be able to access the file.
The operation failed.” usually indicates that the outlook data file, where outlook has all the information stored cannot be opened. Outlook users getting error “ Cannot start Microsoft Outlook.
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